No, Skio is not currently compatible with Shopify B2B. Shopify's B2B feature has several incompatibilities with third-party apps, including subscription apps like Skio.
Why isn't Skio compatible with Shopify B2B?
Shopify B2B uses a different checkout and customer model than standard Shopify stores. According to Shopify's documentation, B2B functionality is incompatible with subscription apps and other features that rely on the standard Shopify checkout flow.